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Why is PRP(Platelet Rich Plasma) beneficial? Platelets contain several growth factors like VEGF (Vasucular endothelial growth factor), PDGF (platelet derived growth factor), TGF (tranformin growth factor), HGF(hepatocyte growth factor) EGF (Epidermal growth factor) IGF (Insulin like growth factor) TSP-1(Thrombospondin-1) FGF(Fibroblast growth factor) These factors increase fibroblast proliferation, collagen deposition, angiogenesis, , extracellular matrix synthesis and soft-tissue regeneration.